Sandoz One Source banner

You can receive your first and subsequent doses of ZARXIO at no cost*

Commercial Co-Pay Program for ZARXIO

The Sandoz One Source Commercial Co-Pay Program for ZARXIO supports eligible,* commercially insured patients with their out-of-pocket co-pay costs for ZARXIO.

Sandoz One Source co-pay details

In-home Injection Training

In the event that you're injecting at home, Sandoz One Source® offers in-home visits where a nurse trainer provides eligible patients with detailed instructions on the administration of ZARXIO.

Sandoz One Source Injection Training Steps

Call 1-844-SANDOZ1 (1-844-726-3691) or talk to your doctor to request in-home injection training.

Patient Support Services

Sandoz One Source provides comprehensive patient support services designed to help simplify and support patient access.

  • Benefit investigations
  • Prior authorization and appeals support
  • Commercial Co-Pay Program
  • Independent foundation information
  • Patient Assistance Program
  • In-home injection training

Medical & Sandoz One Source Contact Card

If you have questions about ZARXIO, please speak with your prescriber.

The information provided here is general information and is not intended to provide reimbursement or legal advice. Furthermore, it is not intended to increase or maximize payment by any payer. Because laws, regulations, and coverage policies are complex and updated frequently, you should check with your local Medicare carrier and payers often or go to

Nothing in the information provided shall be construed as a guarantee of Sandoz regarding levels of reimbursement, payment, or charge that reimbursement will be received. The ultimate responsibility for obtaining reimbursement lies with the physician, provider, or patient. Please consult with your counsel or reimbursement specialist for any practice-specific reimbursement or billing questions.

*Eligibility Requirements: Maximum benefit of $10,000 annually. Prescription must be for an approved indication. This program is not health insurance. This program is for insured patients only; cash-paying or uninsured patients are not eligible. Patients are not eligible if prescription for ZARXIO is paid, in whole or in part, by any state or federally funded programs, including but not limited to Medicare (including Part D, even in the coverage gap) or Medicaid, Medigap, VA, DOD, or TRICARE, or private indemnity plans that do not cover prescription drugs, or HMO insurance plans that reimburse the patient for the entire cost of their prescription drugs, or where prohibited by law. Co-Pay Program may apply to out-of-pocket expenses that occurred within 120 days prior to the date of the enrollment. Co-Pay Program may not be combined with any other rebate, coupon, or offer. Co-Pay Program has no cash value. Sandoz reserves the right to rescind, revoke, or amend this offer without further notice.
Training via video and telephone also available.

ZARXIO and Sandoz One Source are registered trademarks of Novartis AG.


What is ZARXIO?

ZARXIO is a man-made form of granulocyte colony-stimulating factor (GCSF). G-CSF is a substance produced by the body. It stimulates the growth of neutrophils, a type of white blood cell important in the body’s fight against infection.


Do not take ZARXIO if you have had a serious allergic reaction to human G-CSFs such as filgrastim or pegfilgrastim products.

Before you take ZARXIO, tell your doctor about all of your medical conditions, including if you:

  • have a sickle cell disorder.
  • have a problem with your kidneys, as you may need more frequent urine tests.
  • are receiving radiation therapy.
  • are allergic to latex. The needle cap on the prefilled syringe contains natural rubber (derived from latex). Do not handle the prefilled syringe if you are allergic to latex.
  • are pregnant or plan to become pregnant. It is not known if ZARXIO will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if ZARXIO passes into your breast milk.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of ZARXIO?

ZARXIO may cause serious side effects, including:

  • Spleen rupture. Your spleen may become enlarged and can rupture. A ruptured spleen can cause death. Call your doctor right away if you have pain in the left upper stomach (abdomen) area or your left shoulder.
  • A serious lung problem called acute respiratory distress syndrome (ARDS). Call your doctor or get emergency medical help right away if you have shortness of breath with or without a fever, trouble breathing, or a fast rate of breathing.
  • Serious allergic reactions. ZARXIO can cause serious allergic reactions. These reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness, swelling around your mouth or eyes, fast heart rate, and sweating. If you have any of these symptoms, stop using ZARXIO, and call your doctor or get emergency help right away.
  • Sickle cell crises. You may have a serious sickle cell crisis if you have a sickle cell disorder and take ZARXIO. Serious sickle cell crisis has happened in people with sickle cell disorders receiving filgrastim that has sometimes led to death. Call your doctor right away if you have symptoms of sickle cell crisis such as pain or difficulty breathing.
  • Kidney injury (glomerulonephritis). Kidney injury has been seen in patients who received filgrastim products. Call your doctor right away if you experience puffiness in your face or ankles, blood in your urine or brown-colored urine or you notice you urinate less than usual.
  • Capillary leak syndrome. ZARXIO can cause fluid to leak from blood vessels into your body’s tissues. This condition is called “Capillary Leak Syndrome” (CLS). CLS can quickly cause you to have symptoms that may become life-threatening. Get emergency medical help right away if you develop any of the following symptoms:
    • swelling or puffiness and are urinating less often.
    • trouble breathing.
    • swelling of your stomach-area (abdomen) and feeling of fullness.
    • dizziness or feeling faint.
    • a general feeling of tiredness.
  • Decreased platelet count (thrombocytopenia). Your doctor will check your blood during treatment with ZARXIO. Tell your doctor if you have unusual bleeding or bruising while taking ZARXIO. This could mean a decrease of platelets, which reduces the ability of blood to clot.
  • Increased white blood cell count (leukocytosis). Your doctor will check your blood during treatment with ZARXIO.
  • Inflammation of your blood vessels (cutaneous vasculitis). Tell your doctor if you develop purple spots or redness of your skin.
  • Inflammation of the aorta (aortitis). Inflammation of the aorta (the large blood vessel which transports blood from the heart to the body) has been reported in patients who received filgrastim products. Symptoms may include fever, abdominal pain, feeling tired, and back pain. Call your healthcare provider if you experience these symptoms.

The most common side effects of ZARXIO include aching in the bones and muscles.

These are not all the possible side effects of ZARXIO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see full Prescribing Information for ZARXIO.